Dr. Angela Bachi

1991-1993

Research Fellow, Pharmaceutical Analysis & Technology Department of the University of Genoa (Prof. G.Bignardi).

1993-1996

Graduate Student , "Fondazione Lombardia per l'Ambiente". Laboratory of Environmental Pharmacology and Toxicology, Analytical Biochemistry Unit, Mario Negri Institute for Pharmacological Research (Dr. R.Fanelli, Dr. C. Chiabrando).

1997-1999

Postdoctoral Fellow, Protein and Peptide Group, EMBL, Heidelberg. (Dr. M.Mann and Dr.M.Wilm).

December 1999

Research Assistant, Molecular Genetics, DIBIT, H.S.Raffaele Scientific Institute, Milan.

• Parodi B., Caviglioli G., Bachi A., Cafaggi S., Bignardi G. Complex extemporaneous preparations: study of a formulation containing diethylpropion hydrochloride in hard capsules. Acta Technologiae et Legis Medicamenti, III (3), 109. (1992).
• Chiabrando C., Corada M., Bachi A., Fanelli R. Urinary excretion of 2,3-dinor-thromboxane B1, a major metabolite of thromboxane B2 in the rat. Prostaglandins 47: 409-422. (1994).
• Bachi A., Zuccato E., Baraldi M., Fanelli R., Chiabrando C. Measurement of urinary 8-epi-prostaglandin F2a, a novel index of lipid peroxidation in vivo, by immunoaffinity extraction/gas chromatography-mass spectrometry: basal levels in smokers and nonsmokers. Free Radical Biology and Medicine 20 (4): 619-624. (1996).
• Bachi A., Brambilla R., Fanelli R., Bianchi R., Zuccato E. and Chiabrando C. Reduction of urinary 8-epi-prostaglandin F2a during cyclooxygenase inhibition in rats but not in humans. British Journal of Pharmacology 121: 1770-1774. (1997).
• Grüter, P., Tabernero, C., von Kobbe, C., Schmitt, C., Saavedra, C., Bachi, A., Wilm, M., Felber, B.K. and Izaurralde E. TAP, the Human Homolog of Mex67p, Mediates CTE-Dependent RNA Export from the Nucleus. Molecular Cell 1(5): 649-659. (1998).
• Schrotz-King, P., Wilm, M., Andersen, J.S., Ashman, K., Podtelejnikov, A. V., Bachi, A., King, A. and Mann, M. Use of Mass Spectrometric Methods for Protein Identification in Receptor Research. Journal of Receptor and Signal Research: 9/1-4, p. 659-672. (1999).
• Askjaer, P., Bachi, A., Wilm, M., Bischoff, F.R., Weeks, D.L., Ogniewski, V., Ohno, M., Kjems, J., Mattaj I.W. and Fornerod M. RanGTP-Regulated Interactions of CRM1 with Nucleoporins and a Shuttling DEAD-Box Helicase. Molecular and Cellular Biology 19: 6276-6285. (1999).
• Schmitt*, C., von Kobbe*, C., Bachi, A.,* Panté, N., Rodrigues, J.P., Boscheron, C., Rigaut, G., Séraphin, B., Wilm, M., Fonseca, M.C. and Izaurralde, E. Dbp5, a DEAD box-protein required for mRNA export, is recruited to the cytoplasmic fibrils of Nuclear Pore Complex via a conserved interaction with CAN/Nup159p. EMBO J. 18: 4332-4347. (1999).
• Achsel, T., Brahms, H., Kastner, B., Bachi, A., Wilm, M. and Lührmann, R. A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro EMBO J. 1999 18: 5789-5802. (1999).
• De la Torre, B.G.,Albericio, F., Saison-Behmoaras, E., Bachi, A., and Eritja, R. Synthesis and binding properties of oligonucleotides carrying nuclear localization sequences. Bioconjugate Chemistry.Nov-Dec; 10(6):1005-12. (1999).
• Bachi, A.,Grüter, P., Panté, N., Rodrigues, J.P., von Kobbe, C., Braun, I.C., Wilm, M., Fonseca, M.C., Görlich, D. and Izaurralde, E. TAP/hMex67 bridges the interaction between mRNP export substrates and the Nuclear Pore Complex during nuclear export. Submitted.