Dr. Roberta Mazzieri

1990-1993

Research Fellow, Italian Association for Cancer Research, Department of Genetic and Microbiology, University of Pavia (Dr. P. Mignatti).

1992-1995

Ph.D. student, Genetic Science, Department of Genetic and Microbiology, University of Pavia (Dr. P. Mignatti).

1996-1999

Postdoctoral Associate, Department of Cell Biology, New York University, School of Medicine (Dr. D.B. Rifkin).

May 1999

Research Assistant, Molecular Genetics, DIBIT, H.S.Raffaele Scientific Institute, Milan.

• Mignatti, P.,Mazzieri, R. and Rifkin, D.B. Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor. J Cell Biol 113, 1193-201. (1991).
• Vagnarelli, P., Raimondi, E., Mazzieri, R., De Carli, L. and Mignatti, P., Assignment of the human urokinase receptor gene (PLAUR) to 19q13. Cytogenet. Cell Genet. 60, 197-9. (1992).
• Masiero, L., Mazzieri, R., Kalebic, T., Mignatti, P. and Garbisa, S. Modulation of expression and activity of MMP-2 by reducing agents and uPA-plasmin. Eur. J. Histochem. 37, 60-61. (1993).
• Mazzieri, R., Høyer-Hansen, G., Rønne, E., Løber, Vagnarelli, P., Raimondi, E., De Carli, L., Danø, K. and Mignatti, P. Urokinase and urokinase receptor expression in somatic cell hybrids. Fibrinolysis 8, 344-352 (1994)
• Mandriota, S.J., Seghezzi, G., Vassalli, J.D., Ferrara, N., Wasi, S., Mazzieri, R., Mignatti, P. and Pepper, M.S. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J. Biol. Chem. 270, 9709-16. (1995).
• Seghezzi, G., Marelli, R., Mandriota, S.J., Nolli, M.L., Mazzieri, R. and Mignatti, P. Tumor cell-conditioned medium stimulates expression of the urokinase receptor in vascular endothelial cells. J. cell physiol. (1996).
• Gleizes, P.E., Beavis, R.C., Mazzieri, R., Shen, B. and Rifkin, D.B. Identification and caracterization of an eight-cystein repeat of the latent trasforming growth factor-beta binding protein-1 that mediates bonding to the latent trasforming growth factor-beta 1. J. Biol. Chem. 271, 29891-6. (1996).
• Mazzieri, R., Masiero, L., Zanetta, L., Monea, S., Onisto, M., Garbisa, S. and Mignatti P. Control of type IV collagenase activity by components of the urokinase-plasmin system: regulatory mechanism with cell-bound reactants. EMBO J. 16, 2319-32. (1997).
• Munger, J.S., Harpel, J.G., Gleizes, P.E., Mazzieri, R.,, Nunes, I. and Rifkin, D.B. Latent trasforming growth factor-beta: structural features and mechanisms of activation. Kidney Int. 51, 1376-82. (1997).
• Rifkin, D.B., Mazzieri, R., Munger, J.S., Noguera, I. and Sung, J. Proteolytic control of growth factor availability. APMIS. 107, 80-5. (1999).
• Mazzieri, R., Munger, J.S. and Rifkin, D.B. Transforming Growth Factor ß. Protocols. Methods in Molecular Biology, Vol 142. Ed. P. H. Howe Humana Press Inc. Totowa, NJ. In press