Dr. Anna Mondino

1988-1989

Research Fellow, Italian Association for Cancer Research, Department of Biomedical Science and Oncology , University of Turin (Dr. P.M. Comoglio)

1989-1991

Ph.D. student, Molecular Oncology Department of Biomedical Science and Oncology, University of Turin (Dr. G. Gaudino)

1991-1992

Ph.D. student, Molecular Oncology Department of Pharmacology New York University, Medical Center (Dr. J. Schlessinger)

1993-1998

Postdoctoral Associate, Department of Microbiology University of Minnesota, Medical School (Dr. M.K. Jenkins)

April 1998

Research Associate, Molecular Genetics, DIBIT, H. S. Raffaele Scientific Institute, Milan

• Mondino, A., S. Giordano and P.M.Comoglio. Defective post-translational processing activates the tyrosine kinase encoded by the MET/HGF receptor proto-oncogene. Molecular and Cellular Biology, 11: 6084-6092, 1991.
• Giordano, S., M.F. di Renzo, M. Olivero, Mondino, A., Z. Zhen, E. Medico and P.M. Comoglio. The c-MET/HGF receptor in human tumors. European Journal of Cancer Prevention 1 (Supplement 3): 45-49, 1992.
• Nishimura, R., W. Li, A. Kashishian, Mondino, A. M. Zhou, J. Cooper and J. Schlessinger. SH2 and SH3 domain-containing protein Nck shares a binding site with phosphatidylinositol 3-kinase on PDGF B-receptor, implicated in PDGF-induced mitogenesis. Molecular and Cellular Biology 13: 6889-6896, 1993.
• Hu, P., Mondino, A., E. Skolnik and J. Schlessinger. Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Molecular and Cellular Biology 13: 7677-7688, 1993.
• Mondino, A., and M.K. Jenkins. Surface proteins involved in T cell costimulation. Journal of Leukocyte Biology 55: 805-815, 1994.
• Mondino, A., and M.K. Jenkins. Accumulation of sequence-specific RNA-binding proteins in the cytosol of apoptotic T cells. Journal of Biological Chemistry, 270 (44), 26593-26601, 1995.
• Li, W., C.D. Whaley, Mondino, A., and D.L. Mueller. Blocked signal transduction to ERK and JNK protein kinases in anergic CD4+ T cells. Science 271: 1272-12774, 1996.
• Mondino, A.*, Khoruts, A.*, and M.K. Jenkins. The anatomy of T cell activation and tolerance. Proceeding of National Academy of Science USA, 93 (6): 2245-2252, 1996.
• Mondino, A.., De Silva, D.R., Whaley, C.D., Li, W., M.K. Jenkins, and D.L. Mueller. Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB and JunB in anergic Th1 cells. Journal of Immunology, 157: 2048-2057, 1996.
• Pape, K.A., Kearney, E. R., Khoruts, A., Mondino, A., Merica, R., Chen, Z-M., Ingulli, E. G., White, J., Johnson, J. G., and M.K. Jenkins. Use of adoptive transfer of T cell antigen receptor transgenic T cells for the study of T cell activation in vivo. Immunological Review, 156: 67-78, 1997.
• Ingulli, E., Mondino, A., Khoruts, A., and M.K. Jenkins. In vivo detection of dendritic cell antigen-presentation to CD4+ T Cells. Journal of Experimental Medicine, 185: 2133-2141, 1997.
• Pape, K.A., Khoruts, A., Mondino, A., and M.K. Jenkins. Inflammatory cytokines enhances persistence the in vivo clonal expansion and differentiation of antigen-activated CD4+ T cells. Journal of Immunology, 159: 591-598, 1997.
• Khoruts, A.*, Mondino, A.*, Pape, K. A., and M.K. Jenkins. A natural immunological adjuvant enhances T cell clonal expansion in vivo through a CD28-dependent, IL-2-independent mechanism. Journal of Experimental Medicine, 187: 225-236, 1998.
• Pape, K. A., Merica, R., Mondino, A., Khoruts, A., , and M.K. Jenkins. Direct evidence that functionally-impaired CD4+ T cells persist in vivo following induction of peripheral tolerance. Journal of Immunology. 160: 4719-29, 1998.