Dr. Cornelis F.M.Sier

1989-1995

Ph.D student and Postdoc, Dept. Gastroenterology, University Hospital Leiden, The Netherlands (Prof. Dr. C.B.H.W. Lamers).

September 1995

Postdoc AIRC fellowship (AIRC, Italian Association of Cancer Research), Molecular Genetics, DIBIT H.S. Raffaele Scientific Institute, Milan.

• Sier CFM, Fellbaum C, Verspaget HW, Schmitt M, Griffioen G, Graeff H, Hofler H, Lamers CBHW.Immunolocalization of urokinase-type plasminogen activator in adenomas and carcinomas of the colorectum. Histopathology 19, 231-237. (1991).
• Sier CFM, Verspaget HW, Griffioen G, Verheijen JH, Quax PHA, Dooijewaard G, De Bruin PAF, Lamers CBHW. Imbalance of plasminogen activators and their inhibitors in human colorectal neoplasia. Implication for urokinase in colorectal carcinogenesis. Gastroenterology.101, 1522-1528. (1991).
• Sier CFM, Verspaget HW, Griffioen G, Ganesh S, Vloedgraven HJM, Lamers CBHW. Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach. Gut. 34, 80-85. (1993).
• Sier CFM, Quax PHA, Vloedgraven HJM, Verheijen JH, Griffioen G, Ganesh S, Lamers CBHW, Verspaget HW. Increased urokinase receptor levels in human gastrointestinal neoplasia and related liver metastases. Invasion Metastasis. 13, 277-288. (1993).
• Sier CFM, Vloedgraven HJM, Ganesh S, Griffioen G, Quax PHA, Verheijen JH, Dooijewaard G, Welvaart K, Van de Velde CJH, Lamers CBHW, Verspaget HW. Inactive urokinase-type plasminogen activator and increased plasminogen activator inhibitor type-1 are involved in liver metastasis formation of human colorectal cancer. Gastroenterology.107, 1449-1456. (1994).
• Sier CFM, Vloedgraven HJM, Griffioen G, Ganesh S, Nagengast FM, Lamers CBHW, Verspaget HW. Presence and activity of plasminogen activators and inhibitor type-1 in neoplastic colonic tissue from patients with familial adenomatous polyposis. Br J Cancer. 71, 393-396. (1995).
• Sier CFM, Kubben FJGM, Ganesh S, Heerding MM, Griffioen G, Hanemaaijer R, Van Krieken JHJM, Lamers CBHW, Verspaget HW. Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma. Br J Cancer. 74, 413-417. (1996)
• Sier CFM, Stephens R, Bizik J, Mariani A, Bassan M, Pedersen N, Frigerio L, Ferrari A, Dan¯ K, Br¸nner N, Blasi F. The level of urokinase plasminogen activator receptor is increased in serum of ovarian cancer patients. Cancer Res. 58, 1843-1849. (1998).
• Sier CFM, Verheijen JH, Casetta G, Tizzani A, Agape V, Blasi F, Hanemaaijer R. MMP-9 activity in urine from bladder carcinoma patients is associated with tumor grade and tumor stage. (1998) Cancer Res. Submitted.
• Sier CFM, Sidenius N, Mariani A, Aletti G, Agape V, Stephens R, Br¸nner N, Ferrari A, Blasi F. Presence of soluble urokinase receptor in urine of cancer patients and possible clinical relevance. (1998). Cancer Res. Submitted.