Contact:
Prof. Robero Sitia
DiBit-HSR
Via Olgettina 58
20132-Milano-Italy
Tel: +39/02/26434722
Fax: +39/02/26434723
E-mail: r.sitia@hsr.it
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A significant fraction of the total
cellular protein synthesis is devoted to the production of
proteins destined to membranes or to the extracelluar space.
All these proteins begin their journey through the exocytic pathway within the Endoplasmic Reticulum
(ER) where they fold, oligomerize and undergo other post-translational
modifications. All these processes
are under a tight "quality control" schedule that prevents
uncorrectly folded molecules from exiting the ER and
eventually routes them back to the cytosol for proteasomal degradation.
We are exploring this field with a wide range of techniques,
with an emphasis on the processes of disulfide-bonds
formation, degradation and quality control of protein
folding in the ER.
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Molecular
Immunology
