2008
2007
Chiulli N,
Codazzi F, Di Cesare A,
Gravaghi C, Zacchetti
D*, Grohovaz
F* (2007)
Sphingosylphosphocholine effects on cultured astrocytes reveal
mechanisms potentially involved in neurotoxicity in Niemann-Pick type A
disease
Eur. J. Neurosci. 26:875–881 (* corresponding authors)
doi:10.1111/j.1460-9568.2007.05732.x
Mihailovich M, Thermann R, Grohovaz
F, Hentze MW, Zacchetti
D (2007)
Complex
translational regulation of BACE1 involves upstream uAUGs and
stimulatory elements within the 5' untranslated region
Nucl. Acids Res. 35:2975-2985.
full
text
Zacchetti
D, Chieregatti E, Bettegazzi B, Mihailovich M,
Sousa VL, Grohovaz F,
Meldolesi J (2007)
BACE1 expression and activity: relevance in Alzheimer’s disease
Neurodegenerative Dis. 4:117-126 (review)
2006
2005
Negri L, Lattanzi R, Giannini E, Colucci MA, Mignogna G, Barra D, Grohovaz F, Codazzi F, Kaiser A, Kreil G, Melchiorri P. (2005)2004
De Pietri Tonelli D.*, Mihailovich M.*, Di Cesare A., Codazzi F., Grohovaz F. and Zacchetti D. (2004)2003
De Pietri Tonelli D., Mihailovich M., Schnurbus
R., Pesole G., Grohovaz F., and Zacchetti D. (2003)
Translational
control of Scamper expression via a cell-specific internal ribosome
entry site.
Nucl. Acids Res. 31: 2508-2513
full
text
2002
Ehehalt R., Michel B., De Pietri Tonelli D., Zacchetti
D., Simons K., and Keller P. (2002)
Splice
variants of the beta-site APP-cleaving enzyme BACE1 in human brain and
pancreas
Biochem. Biophys. Res. Comm. 293: 30-37
Schnurbus R., De Pietri Tonelli D., Grohovaz
F.,
and Zacchetti D. (2002)
Re-evaluation
of primary structure, topology, and localization of Scamper, a putative
intracellular Ca2+ channel activated by spingosylphosphocholine.
Biochem. J. 362: 183-189
Bertuzzi F., Grohovaz F., Maffi P., Caumo A., Aldrighetti L.,
Nano
R., Hengster P., Calori G., Di Carlo V., Bonifacio E., and Secchi A.
(2002)
Succesful
transplantation of human islets in recipients bearing a kidney graft.
Diabetologia 45: 77-84
2001
Pezzati R., Meldolesi J., and Grohovaz F. (2001)
Ultra
rapid calcium events in electrically stimulated frog nerve terminals.
Biochem. Biophys. Res. Comm. 2001; 285:724-727
Meldolesi J. and Grohovaz F. (2001)
Total
calcium ultrastructure: advances in excitable cells.
Cell Calcium 2001; 30: 1-8 (review)
Codazzi F., Teruel M.N., and Meyer T. (2001)
Control
of astrocyte Ca2+ oscillations and waves by oscillating translocation
and activation of protein kinase C.
Curr. Biol. 2001; 11: 1089-1097
2000
Haugh J.M., Codazzi F., Teruel M., and Meyer T. (2000)
Spatial
sensing in fibroblasts mediated by 3' phosphoinositide.
J. Cell Biol. 151: 1269-1279
Lorenzon P., Grohovaz F., and Ruzzier F. (2000)
Voltage-
and ligand-gated ryanodine receptors are functionally separated in
developing C2C12 mouse myotubes.
J. Physiol. 525.2: 499-507
Benting J., Lecat S., Zacchetti D., and Simons K. (2000)
Protein
expression in Drosophila Schneider cells.
Analytical Biochemistry 278: 59-68
1999
Bertuzzi F., Davalli A.M., Nano R., Socci C., Codazzi F., Fesce
R., Di
Carlo V., Pozza G., and Grohovaz F. (1999)
Mechanisms
of Coordination of Ca2+ Signals in Pancreatic Islet Cells.
Diabetes 48: 1971-1978
Tonini R., Grohovaz F., Laporta C.A.M., and Mazzanti M. (1999)
Gating
mechanism of the nuclear pore complex channel in isolated neonatal and
adult mouse liver nuclei.
Faseb J. 13: 1395-1403
Cheong K.H., Zacchetti D., Schneeberger E.E., and Simons K.
(1999)
VIP17/MAL,
a lipid raft-associated protein, is involved in apical transport in
MDCK cells.
Proc. Natl. Acad. Sci. USA. 96: 6241-8
Improta Brears T., Whorton A.R., Codazzi F., York J.D., Meyer
T.,
McDonnell D.P. (1999)
Estrogen-induced
activation of mitogen-activated protein kinase requires mobilization of
intracellular calcium.
Proc. Natl. Acad. Sci. USA. 96: 4686-91
Kasai H., Kishimoto T., Liu T.T., Miyashita Y., Podini P., Grohovaz
F., and
Meldolesi J. (1999)
Multiple
and diverse forms of regulated exocytosis in wild-type and defective
PC12 cells.
Proc. Natl. Acad. Sci. USA. 96: 945-9
Pezzati R. and Grohovaz F. (1999)
The
frog neuromuscular junction revisited after
quick-freezing-freeze-drying: ultrastructure, immunogold labelling and
high resolution calcium mapping.
Philos. Trans. R. Soc. Lond. B. Biol. Sci. 354: 373-8
1998
Martino G., Grohovaz F.,
Brambilla E., Codazzi F.,
Consiglio A., Clementi E., Filippi M., Comi G., and Grimaldi L.M. (1998)
Proinflammatory
cytokines regulate antigen-independent T-cell activation by two
separate calcium-signaling pathways in multiple sclerosis patients.
Ann. Neurol. 43: 340-9
1997
Pezzati R., Bossi M., Podini P., Meldolesi J., and Grohovaz F.
(1997)
High-resolution
calcium mapping of the endoplasmic reticulum-Golgi-exocytic membrane
system. Electron energy loss imaging analysis of quick frozen-freeze
dried
PC12 cells.
Mol. Biol. Cell. 8: 1501-12
1996
Grohovaz F., Bossi M., Pezzati R., Meldolesi J., and Torri-Tarelli
F.
(1996)
High
resolution ultrastructural mapping of total calcium: electron
spectroscopic imaging/electron energy loss spectroscopy analysis of a
physically/chemically processed nerve-muscle preparation.
Proc. Natl. Acad. Sci. U.S.A. 93: 4799-803
Codazzi F., Racchetti G., Grohovaz F., and Meldolesi
J. (1996)
Transduction
signals induced in rat brain cortex astrocytes by the HIV-1 gp120
glycoprotein.
FEBS Lett. 384: 135-7
Bertuzzi F., Zacchetti D., Berra C., Socci C., Pozza G.,
Pontiroli A.E., and Grohovaz F.
(1996)
Intercellular
Ca2+ waves sustain coordinate insulin secretion in pig islets of
Langerhans.
FEBS Lett. 379: 21-5
1995
D'Andrea P. and Grohovaz F. (1995)
[Ca2+]i
oscillations in rat chromaffin cells: frequency and amplitude
modulation by Ca2+ and InsP3.
Cell Calcium 17: 367-74
Codazzi F., Menegon A., Zacchetti D., Ciardo A., Grohovaz
F., and
Meldolesi J. (1995)
HIV-1
gp120 glycoprotein induces [Ca2+]i responses not only in type-2 but
also type-1 astrocytes and oligodendrocytes of the rat cerebellum.
Eur. J. Neurosci. 7: 1333-41
Lorenzon P.*, Zacchetti D.*, Codazzi F.,
Fumagalli G., Meldolesi J., and Grohovaz F. (1995)
Ca2+
waves in PC12 neurites: a bidirectional, receptor-oriented form of Ca2+
signaling.
J. Cell Biol. 129: 797-804 (* shared contribution)
Zacchetti D., Peranen J., Murata M., Fiedler K., and Simons
K. (1995)
VIP17/MAL,
a proteolipid in apical transport vesicles.
FEBS-Lett. 377: 465-9
Bastianutto C., Clementi E., Codazzi F., Podini P., De Giorgi
F.,
Rizzuto R., Meldolesi J., and Pozzan T. (1995)
Overexpression
of calreticulin increases the Ca2+ capacity of rapidly exchanging Ca2+
stores and reveals aspects of their lumenal microenvironment and
function.
J. Cell Biol. 130: 847-55
Ceccaldi P.E., Grohovaz F., Benfenati F., Chieregatti E.,
Greengard P., and Valtorta F. (1995)
Dephosphorylated
synapsin I anchors synaptic vesicles to actin cytoskeleton: an analysis
by videomicroscopy.
J. Cell Biol. 128: 905-12
1994
D'Andrea P., Codazzi F., Zacchetti D., Meldolesi J., and
Grohovaz F. (1994)
Oscillations
of cytosolic calcium in rat chromaffin cells: dual modulation in
frequency and amplitude.
Biochem. Biophys. Res. Commun. 205: 1264-9
Fesce R., Grohovaz F., Valtorta F., and Meldolesi J. (1994)
Neurotransmitter
release: fusion or 'kiss-and-run'?
Trends in Cell Biology, 4:1-4 (review)
1993
Grohovaz F., Lorenzon P., Ruzzier F., and Zorec R. (1993)
Properties
of acetylcholine receptors in adult rat skeletal muscle fibers in
culture.
J-Membr-Biol. 136: 31-42
D'Andrea P., Zacchetti D., Meldolesi J., and Grohovaz F. (1993)
Mechanism
of [Ca2+]i oscillations in rat chromaffin cells. Complex
Ca(2+)-dependent regulation of a ryanodine-insensitive oscillator.
J. Biol. Chem. 268: 15213-20
Valtorta F., Ceccaldi P.E., Grohovaz F., Chieregatti E., Fesce
R., and
Benfenati F. (1993)
Fluorescence
approaches to the study of the actin-nucleating and bundling activities
of synapsin I.
J. Physiol. Paris 87: 117-22 (review)
Grohovaz F., Zacchetti D., Lorenzon P.,
Meldolesi J., and D'Andrea P. (1993)
Receptor-mediated
intracellular signalling: oscillations and waves of cytosolic calcium.
Biochem. Soc. Trans. 21: 1129-32 (review)
1992
Torri Tarelli F., Bossi M., Fesce R., Greengard P., and Valtorta
F. (1992)
Synapsin-I
partially dissociates from synaptic vesicles during exocytosis induced
by electrical stimulation.
Neuron 9:1143-1153
Clementi E., Racchetti G., Zacchetti D., Panzeri M.C., and
Meldolesi J. (1992)
Differential
expression of markers and activities in a group of PC12
nerve cell clones.
Europ. J. Neurosci., 4: 944-953
Clementi E., Scheer H., Zacchetti D., Fasolato C., Pozzan T.,
and
Meldolesi J. (1992)
Receptor-activated
Ca2+ influx. Two independently regulated mechanisms of influx
stimulation coexist in neurosecretory PC12 cells.
J. Biol. Chem. 267: 2164-72
Meldolesi J., Villa A., Podini P., Clementi E., Zacchetti D., D'Andrea
P.,
Lorenzon P., and Grohovaz F. (1992)
Intracellular
Ca2+ stores in neurons. Identification and functional aspects.
J. Physiol. Paris 86: 23-30 (review)
1991
Torri Tarelli F., Passafaro M., Clementi F., and Sher E. (1991)
Presynaptic
localization of -conotoxin-sensitive calcium channels at
the frog neuromuscular junction.
Brain Res. 547:331-334
Zacchetti D., Clementi E., Fasolato C., Lorenzon P.,
Zottini M., Grohovaz F., Fumagalli G., Pozzan T., and Meldolesi
J. (1991)
Intracellular
Ca2+ pools in PC12 cells. A unique, rapidly exchanging pool is
sensitive to both inositol 1,4,5-trisphosphate and caffeine-ryanodine.
J. Biol. Chem. 266: 20152-8
Fasolato C., Zottini M., Clementi E., Zacchetti D., Meldolesi
J., and
Pozzan T. (1991)
Intracellular
Ca2+ pools in PC12 cells. Three intracellular pools are distinguished
by their turnover and mechanisms of Ca2+ accumulation, storage, and
release.
J. Biol. Chem. 266: 20159-67
Grohovaz F., Zacchetti D., Clementi E., Lorenzon
P.,
Meldolesi J., and Fumagalli G. (1991)
[Ca2+]i
imaging in PC12 cells: multiple response patterns to receptor
activation reveal new aspects of transmembrane signaling.
J. Cell Biol. 113: 1341-50
Meldolesi J., Clementi E., Fasolato C., Zacchetti D., and
Pozzan T. (1991)
Ca2+
influx following receptor activation.
Trends Pharmacol. Sci. 12: 289-92 (review)
Grohovaz-F; Zacchetti-D; D'-Andrea-P; Lorenzon-P;
Meldolesi-J (1992)
[Ca2+]i
effects of bradykinin B2 receptor activation in PC12 cells.
Agents-Actions-Suppl. 38(Pt 2): 9-15
Clementi E, Scheer H, Zacchetti D, Racchetti G, Meldolesi J
(1992)
PC12
cell clones: experimental tools for studying transmembrane signalling
and Ca2+ stores.
Pharmacol. Res. 25 Suppl 1:95-6
Zacchetti-D; Lorenzon-P; Scheer-H; Clementi-E;
Meldolesi-J; Fumagalli-G; Grohovaz-F (1992)
Receptor
activation and Ca2+ homeostasis studied by videoimaging.
Pharmacol-Res. 1992 Feb-Mar; 25 Suppl 1: 93-4
Fumagalli-G; Zacchetti-D; Lorenzon-P; Grohovaz-F (1991)
Fluorimetric
approaches to the study of calcium transients in living cells.
Cytotechnology. 1991; 5 Suppl 1: 99-102
Meldolesi J, Gatti G, Grohovaz F.
Role of Ca2+ in the regulation of energy metabolism in neurons and
nerve
cells.
In Neuroenergetics: relevance for functional brain imaging. Frackowiak
R.S.J,
Magistretti P.J., Shulman R.G., Altman J.S., Adams M. eds. HFSP
Workshop
XI, 107-117 (2001)
Fumagalli G, Zacchetti D, Verderio C, Codazzi
F, Grohovaz F
Variazioni spaziali e temporali della concentrazione citosolica
dello
ione calcio in cellule viventi.
In "Marcello Malpighi Scienziato Universale" da "Studi e memorie per la
storia dell'Universita' di Bologna" nuova serie vol IX, a cura di
Bernabeo e Pallotti, 1995
R. Fesce and D. Zacchetti.
Calcium fluxes and distribution in neurons.
In "Bioelectrochemistry IV". Nerve-muscle function", G. Milazzo Ed,
1994.
J. Meldolesi, A. Villa, P. D'Andrea, P. Lorenzon, E.
Clementi and F. Grohovaz.
[Ca2+]i control in rat chromaffin cells and PC12 cells.
J. Endocrinol. Invest. 16(s),15, 1993.
J. Meldolesi, A. Ciardo, A. Villa and F. Grohovaz.
Intracellular Ca2+ stores: why, where and how.
In: New Developments in Lipid-Protein Interactions and Receptor
Function. K. W. A. Wirtz ed., Plenum Press, New York-London, 1993.
Zacchetti-D; Lorenzon-P; Fumagalli-G; Grohovaz
F
Analisi spettrofluorimetrica quantitativa di transienti ionici in
cellule in coltura.
Microscopia Elettronica 1991; 12: 51-57
F. Ruzzier, F. Grohovaz, P. Lorenzon and R. Zorec.
Properties of acetylcholine receptors in isolated skeletal muscle
fibres in culture.
In: Restorative Neurology, (Wernig ed.) 5:145-150, Elsevier
North-Holland, 1991.
Submissions to public sequence databases
Accession number AF338816
Michel B, De Pietri Tonelli D, Zacchetti D and Keller P
(2001)
Homo sapiens beta-site APP cleaving enzyme type B mRNA, complete cds
(BACE-1B)
Accession number AF338817
Zacchetti D, De Pietri Tonelli D and Schnurbus R
(2001)
Homo sapiens beta-site APP cleaving enzyme type C mRNA, complete cds
(BACE-1C)
Accession number AF324837
Zacchetti D, Schnurbus R, De Pietri Tonelli D
(2000)
Homo sapiens beta-site APP cleaving enzyme mRNA, partial cds,
alternatively spliced
Accession number AF263546
Zacchetti D, Schnurbus R, De Pietri Tonelli D
(2000)
Scamper (Canis familiaris)
Accession number X92505
Zacchetti D (1995)
VIP17/MAL (Canis familiaris)